Primary biliary cirrhosis is an autoimmune disease in which the body begins fighting its own cells. Sometimes called PBC, this is a condition in which bile ducts in the liver are destroyed, allowing harmful substances to build up in the liver. People with PBC can remain symptom-free for years. Early symptoms can include fatigue, itchy skin and dry mouth. Advanced symptoms can include jaundice (yellowing of the skin and whites of the eyes), pain in the abdomen, muscles or joints, darkening of the skin and elevated cholesterol levels. People in the later stages may also experience swollen feet and ankles, steatorrhea (greasy diarrhea) and fluid buildup in the abdomen due to liver failure.